Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Williams Syndrome is a developmental disorder that is characterized by cardiovascular problems, particular facial features and several typical behavioral and neurological abnormalities. In Williams Syndrome patients, a heterozygous deletion is present of a region on chromosome 7q11.23 (the Williams Syndrome critical region), which spans approximately 20 genes. Two of these genes encode proteins that regulate dynamic aspects of the cytoskeleton of the cell, either via the actin filament system (LIM kinase 1, or LIMK1), or through the microtubule network (cytoplasmic linker (...) protein of 115 kDa, or CLIP‐115). The recent findings that knockout mice lacking LIMK1 or CLIP‐115 have distinct neurological and behavioural phenotypes, indicates that cytoskeletal defects might play a role in the development of neurological symptoms in Williams Syndrome patients. In this review, we discuss the properties of LIMK and CLIP family proteins, their function in the regulation of the actin and microtubule cytoskeletal systems, respectively, and the relationship with neurodevelopmental aspects of Williams Syndrome. BioEssays 26:141–150, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Several themes can be identified in the commentaries. The first is that the climbing fibers may have more than one function; the second is that the climbing fibers provide sensory rather than motor signals. We accept the possibility that climbing fibers may have more than one function consequence(s)’ in the title. Until we know more about the function of the inhibitory input to the inferior olive from the cerebellar nuclei, which are motor structures, we have to keep open the possibility (...) that the climbing fiber signals can be a combination of sensory and motor signals. (shrink)

The search for knowledge has continued to expand to new domains since its start in the seventeenth century. Some of them have proved unusually resistant. Methods have had to proliferate to deal with the obstacles, for example in the social domain. There also have been ideological reactions. Surprisingly frequently, methods and activities that appear to be effective in dealing with such domains are classified as "preliminary" or are distinguished by a "point of view" that has yet to be transcended to (...) achieve "true" knowledge. One such activity is the acquisition of high quality experience. It is argued in the paper that it does not deserve being treated as a poor relative. It has a history of its own and can point to many successes, for example in the development of new values and emotions. Its only drawback seems to be that the search for high quality experiences has tended to be heuristic, or if one wishes, artistic. This situation is changing, however. In the paper the differences between the acquisition of knowledge and that of high quality experience are delineated. It is argued that facilitation of the latter's searches requires the development of interactions between entities that generate and structure experiences--i.e., of human collectives that stabilise sufficiently to execute a collective action in their environment. They are characterised by the use of coordinating languages. (shrink)

: Discussions of ethical approaches in nursing have been much enlivened in recent years, for instance by new developments in the theory of care. Nevertheless, many ethical concepts in nursing still need to be clarified. The purpose of this contribution is to develop a fundamental ethical view on nursing care considered as moral practice. Three main components are analyzed more deeply--i.e., the caring relationship, caring behavior as the integration of virtue and expert activity, and "good care" as the ultimate goal (...) of nursing practice. For the development of this philosophical-ethical interpretation of nursing, we have mainly drawn on the pioneering work of Anne Bishop and John Scudder, Alasdair MacIntyre, Lawrence Blum, and Louis Janssens. We will also show that the European philosophical background offers some original ideas for this endeavor. (shrink)

Next SectionIn this remark, I first show that a Lewis–Kratzer–von Fintel style semantics of conditionals and modals (Lewis 1973; Kratzer 1991a, b; von Fintel 1994; a.o.) together with the downward-entailing-based (DE-based) approach to the licensing of negative polarity items (NPIs) incorrectly predicts that NPIs are ungrammatical in the if-clause of a conditional with a possibility modal in the main clause (i.e., a conditional of the form if p, ◊q; henceforth, CPM; e.g., If John has ever been to Paris, he might (...) become a good chef). I then list three possible solutions to this problem to be explored in future work. (shrink)

Many predator species feed on prey that fluctuates in abundance from year to year. Birds of prey can face large fluctuations in food abundance i.e. small mammals, especially voles. These annual changes in prey abundance strongly affect the reproductive success and mortality of the individual predators and thus can be expected to influence their population dynamics and persistence. The barn owl, for example, shows large fluctuations in breeding success that correlate with the dynamics in voles, their main prey species. Analysis (...) of the impact of fluctuations in vole abundance with a simple predator prey model parameterized with literature data indicates population persistence is especially affected by years with low vole abundance. In these years the population can decline to low owl numbers such that the ensuing peak vole years cannot be exploited. This result is independent of the length and regularity of vole fluctuations. The relevance of this result for conservation of the barn owl and other birds of prey that show a numerical response to fluctuating prey species is discussed. (shrink)

The purpose of this article is to examine Salvian of Marseilles’ (ca. 400–490 CE) invective in De gubernatione Dei against his Christian audience pertaining to their sexual roles and behaviour as slaveholders. It is argued that rather than considering the oppressive practice of slavery in itself as a reason for moral rebuke and divine punishment, Salvian highlights the social shame that arose from the sexual vices Christian slaveholders committed with their slaves. Salvian forwards three accusations against his opponents that concern (...) slavery and sexual vice. Firstly, he asserts that Christian slaveholders have no self-control. Secondly, the polyamorous relationships slaveholders have with numerous slaves resemble shameful and adulterous unions, namely concubinage and even polygamy. Thirdly, Roman-Christian slaveholders behave in a worse manner than barbarians (i.e. the argument of ethnicity). Each of these accusations is examined in detail in the study. (shrink)

The purpose of this article is to examine Theodoret of Cyrus’s (ca. 393–ca. 457 CE) exposition of LXX Ruth, as found in his Questions on the Octateuch. At the centre of this analysis lies the question of what an early Christian author like Theodoret, who lives in a context where asceticism and sexual renunciation were quite popular (i.e. Christian Syria), does with a complicated text like Ruth, which contains so many explicit nuances about sex, procreation and marriage, as well as (...) various gendered complexities. The article starts by examining briefly the canonisation history of Ruth in early Christianity and some of the main interpretative trends in readings of Ruth by other Christian authors. Then, Theodoret’s interpretation of Ruth is examined, focusing specifically on his Questions on Ruth. The purpose of Ruth as scripture, according to Theodoret, is first delineated, after which Theodoret’s approach to sex and gender in LXX Ruth is examined.Contribution: This article argues that Theodoret transforms the story of Ruth into one that aligns with the moral-philosophical discourse related to sex, marriage and gender of his own time. Theodoret restructures Ruth androcentrically by placing Boaz, the masculine and virtuous male father-figure, at the centre of the story, while at the same time stripping Ruth of any possible agency she might have as a would-be temptress. (shrink)

In “Imaging or Imagining? A Neuroethics Challenge In- The assumption at issue here is the assumption that the formed by Genetics,” Judy Illes and Eric Racine (see this ismind literally is the brain (i.e., is numerically identical to sue) argue that “traditional bioethics analysis” (TBA), as de-.

L.S. Vygotsky’s “regulative” account of the development of human thinking hinges on the centralization of “directive” speech acts (commands or imperatives). With directives, one directs the activity of another, and in turn begins to “self-direct” (or self-regulate). It’s my claim that Vygotsky’s reliance on directives de facto keeps his account stuck at Tomasello's level of individual intentionality. Directive speech acts feature prominently in Tomasello’s developmental story as well. But Tomasello has the benefit of accounting for a functional differentiation in directive (...) communication—i.e., in collaborative activity, the command gives way to both the request and informational assertion. Lacking such differentiation, Vygotsky’s account runs the risk of playing to a rather strident conception of the socius, one more Machiavellian than Marxist. (shrink)

The paper develops a eudaimonistic reading of the Zhuāngzǐ 莊子 on which the characteristic feature of a well-lived life is the exercise of dé 德 in a general mode of activity labeled yóu 遊 . I argue that the Zhuāngzǐ presents a second-order conception of agents’ flourishing in which the life of dé is not devoted to predetermined substantive ends or activities with a specific substantive content. Rather, it is marked by a distinctive manner of activity and certain characteristic attitudes. (...) Zhuangist eudaimonism differs from virtue ethics, I suggest, since dé is not moral virtue nor is it normatively basic. The paper discusses textual evidence that the Zhuāngzǐ presents eudaimonistic ideals, develops the Zhuangist conception of “wandering” in detail, and explores connections between wandering and the Zhuangist interest in skill. It surveys the justification for Zhuangist eudaimonism and sketches how the wandering ideal affects the substantive content of a good life. (shrink)

The intuitions at the core of environmental ethics and of other neglected value realms put pressure on traditional anthropocentric ethics based on monistic value theories. Such pressure is so severe that it has led many to give up on the idea of monistic value theories altogether. I argue that value monism is still preferable to value pluralism and that, indeed, these new challenges are opportunities to vastly improve impoverished traditional theories. I suggest an alternative monistic theory, Richness Theory, and show (...) how it provides an opportunity to capture the needs of both environmental ethics and of our traditional ethics. (shrink)

I argue that the overt subjugation in the system of American slavery and its subsequent effects offer a case study for an existentialist analysis of freedom, oppression and humor. Concentrating on the writings and experiences of Frederick Douglass and the existentialists Simone De Beauvoir and Lewis Gordon, I investigate how the concepts of “spirit of seriousness”, “mystification”, and an existentialist reading of “double consciousness” for example, can elucidate the forms of explicit and concealed oppression. I then make the case that (...) subversive humor is an effective means to bring to consciousness the inconsistencies and incongruities of the serious oppressors. I also illustrate how humor can act as a bulwark against the rise and persistence of oppression by (non-violently) attacking the absolutist stance on human nature maintained through the use of dominating and “authoritative” language and action. (shrink)

The majority of philosophers of religion, at least since Plantinga’s reply to Mackie’s logical problem of evil, agree that it is logically possible for an omnibenevolent, omniscient, and omnipotent God to exist who permits some of the evils we see in the actual world. This is conceivable essentially because of the possible world known as heaven. That is, heaven is an imaginable world in a similar way that logically possible scenarios in any fiction are imaginable. However, like some of the (...) imaginable stories in fiction where we are asked to envision an immoral act as a moral one, we resist. I will employ the works of Tamar Gendler on imaginative resistance and Keith Buhler’s Virtue Ethics approach to moral imaginative resistance and apply them to the conception of heaven and the problem of evil. While we can imagine God as an omnibenevolent parent permitting evil to allow for morally significant freedom and the rewards in heaven or punishments in hell (both possible worlds), we should not. This paper is not intended to be a refutation of particular theodicies; rather it provides a very general groundwork connecting issues of horrendous suffering and imaginative resistance to heaven as a possible world. (shrink)

The fact that humans are responsible for climate change is certain. But the meaning of the fact of human responsibility is not disclosed by stating the fact: there is a distinction between the two principles, de facto and de jure, the right to state a fact and the right to assert the meaning of the fact. This distinction must be preserved in order that humans may interpret the nature of our responsibility, as a form of justice. In fact, the nature (...) of human responsibility can never be exhaustively determined. To recognise the fact of human responsibility for climate change may only lead us to acknowledge that climate change coincides with the plundering and exploitation of the earth as a natural resource, together with the industrial pollution which fouls our atmosphere. It is something else again to know precisely what must be done, how to think and write and interpret the science, or even what can be achieved before it is too late to prevent the worst effects of global warming. In this essay I analyse the central claims of proponents of the idea of the Anthropocene, arguing that they are arrogant and perhaps even naïve: in particular, the suggestion that humanity and nature have now fused to become a geological force is shown to be theological in its orientation. The essay also exposes Anthropocenology as a form of pedagogy, meaning that rather than opposing the neoliberalism that it attacks, Anthropocenology joins itself to the biopolitical institutions of education, seizing power in order to govern a totalized human population all the more effectively. (shrink)

To understand how compliance develops both in everyday and corporate environments, it is crucial to understand how different mechanisms work together to shape individuals’ (non)compliant behavior. Existing compliance studies typically focus on a subset of theories (i.e., rational choice theories, social theories, legitimacy theories, capacity theories, and opportunity theories) to understand how key variables from one or several of these theories shape individual compliance. The present study provides a first integrated understanding of compliance, rooted in complexity science, in which key (...) elements from these theories are considered simultaneously, and their relations to compliance and each other are explored using network analysis. This approach is developed by analyzing online survey data (_N_ = 562) about compliance with COVID-19 mitigation measures. Traditional regression analysis shows that elements from nearly all major compliance theories (except for social theories) are associated with compliance. The network analysis revealed groupings and interconnections of variables that did not track the existing compliance theories and point to a complexity overlooked in existing compliance research. These findings demonstrate a fundamentally different perspective on compliance, which moves away from traditional narrow, non-network approaches. Instead, they showcase a complexity science understanding of compliance, in which compliance is understood as a network of interacting variables derived from different theories that interact with compliance. This points to a new research agenda that is oriented on mapping compliance networks, and testing and modelling how regulatory and management interventions interact with each other and compliance within such networks. (shrink)

According to Manuel Davenport, “The best humorists--Mark Twain, Will Rogers, Bob Hope, and Mort Sahl--share [a] mixture of detachment and desire, eagerness to believe, and irreverence concerning the possibility of certainty. And when they become serious about their convictions--as Twain did about colonialism…they cease to be humorous” (p. 171). I agree with the first part, but not the second. Humor does require disengagement, but not completely such that one has no emotional interest in the subject of the humor. Humor does (...) require some degree of commitment to value, but, as Davenport rightly notes, it “despairs of absolutes.” Following Bertrand Russell, “humorous” and “serious” are not antonyms. Davenport does not provide examples of Twain’s attempts at satire that fail to be humorous due to being serious. I will examine some of the very serious issues Twain addresses through irony and humor, and make the case that his commentary and argument, though serious, is still funny while not falling into frivolity. There is a philosophical thread running through his scathing humor, and it largely centers around his raising awareness about, and then deflating, what I would call a “spirit of seriousness”, borrowing from Jean-Paul Sartre and Simone De Beauvoir. For De Beauvoir, expanding on Sartre’s conception, a spirit of seriousness manifests from serious people who attempt to find comfort in the firm, unchanging foundations and values that are seen to be pre-determined, and thus unquestionable. In Twain’s case, it is arrogance and a presumed sense of certitude. This destructive combination sustains many of the institutions (some of them quite “peculiar”) that he attacks: racism, slavery, colonialism, excesses of capitalism, and the often dogmatic and oppressive nature of organized religion: “What gets us into trouble is not what we don’t know; it’s what we know for sure that just ain’t so.” Complacency, self-satisfaction, disinclination to self-monitoring, all lead to closed mode, or rather, to sustaining a serious mode which can spillover into a “spirit of seriousness” if not checked. The quickest path to a feeling of being certain is cultivated ignorance, where doubt and confusion, ambiguity and fluidity are glossed over. This feeling or attitude, the “spirit of seriousness”, is what Twain confronts with serious humor, motivating his readers to consider where their ideals and reality contradict. (shrink)

The image of “the good nurse” is mainly studied from the perspective of nurses, which often does not match the image held by patients. Therefore, a descriptive study was conducted to examine oncology patients’ perceptions of “the good nurse” and the influence of patient- and context-related variables. A cross-sectional, comparative, descriptive design was used. The sample comprised 557 oncology patients at one of six Flemish hospitals, where they were treated in an oncology day-care unit, oncology hospital ward, or palliative care (...) unit. Data were collected using the Flemish Care-Q instrument. Factor analysis summarised the most important characteristics of “the good nurse”. We reassessed the reliability and construct validity of the Flemish Care-Q and examined the influence of patient- and context-related variables on patient perceptions. Using factor analysis, we grouped the different items of the Flemish Care-Q according to three characteristics: “the good nurse” (I) has a supportive and communicative attitude towards patient and family, (II) is competent and employs a professional attitude, and (III) demonstrates personal involvement towards patient and family. Median factor scores of Factors I, II, and III, respectively, were 8.00, 9.00, and 8.00 (varying from 1, not important, to 10, very important). In order of importance, Factors II, I, and III were identified as valuable characteristics of “the good nurse”. Gender, care setting, and province were influential variables. As perceived by oncology patients, “the good nurse” has a broad range of qualities, of which competence and professionalism are the most valuable. (shrink)

Le franciscain Guiral Ot inclut, dans son commentaire sur I Corinthiens, des questions discutées aussi dans son commentaire sur l’ Éthique et dans ses questions parisiennes sur les Sentences (1327-1328). Cet article fournit une tabula quaestionum des commentaires de Guiral Ot sur I Cor. et sur l’Épître aux Galates, ainsi que l’édition de deux questions, l’une tirée du commentaire sur l’ Éthique et l’autre des questions sur l’ Éthique et sur les Sentences. Une analyse révèle que les lectures sur I (...) Cor., données à Toulouse entre l’automne 1323 et le printemps 1326, ont suivi la composition du commentaire sur l’ Éthique, également rédigé à Toulouse, probablement pas avant l’année universitaire 1322-1323. (shrink)

Over the past thirty years or so, theoretical work in such fields as legal semiotics and law and literature has argued that the legal process is profoundly rhetorical. At the same time, a number of communication-based disciplines such as semiotics, sociolinguistics and linguistic anthropology have provided, particularly in interdisciplinary combination with law, a wealth of empirical evidence on, and insight into, the micro-contexts of language and communication in the legal process. However, while these invaluable nitty-gritty analyses provide empirical support for (...) a rhetorical thesis, work in these areas has tended to ignore rhetoric as an explanatory principle. This article introduces an overarching rhetorical framework for the discursive construction and management of cases in contemporary Anglo-American legal processes. Taking ‘forensic’ as relating to the conduct of cases and ‘discourse’ as semiosis-in-practice, I argue that the practices within which forensic discourse is embedded are not, as the received legal view would have it, aimed at revealing an impartial truth but are deeply rhetorical practices aimed at persuading decision-makers to provide a remedy for a claimed wrong. By looking across forensic texts and contexts, I identify common elements of forensic discourse that can be found both in classical forensic orations and throughout the modern legal process and consider how these intersect with critical forces of agency and structure and the particularities of semiosis in situated context. An awareness of commonalities across forensic discourse can help sharpen our focus on the critical causes and consequences of individual and structural difference and point to consequential suggestions for reform. (shrink)

Method, metaphysics, metaphor: three words with a common prefix, which, for philosophy, bear an ancient pedigree. Classically, the last word, as an object of philosophical reflection, has mostly been excluded from bearing any philosophical significance; we will see how this can no longer be the case today, precisely for phenomenology. If the “method” of phenomenology is wholly determined by its goal, namely, "pure" description, and if description is paradoxically only actualized in a figurative mode through guiding metaphors, then we are (...) compelled to ask after the meaning of such a situation for metaphysics, understood as the "redundance" or "affirmation" of existence in its declaration of itself as truth— precisely, I suggest, the work done by metaphor in its strange interlacing of being and human being in the event of language. (shrink)

Method, metaphysics, metaphor: three words with a common prefix, which, for philosophy, bear an ancient pedigree. Classically, the last word, as an object of philosophical reflection, has mostly been excluded from bearing any philosophical significance; we will see how this can no longer be the case today, precisely for phenomenology. If the “method” of phenomenology is wholly determined by its goal, namely, "pure" description, and if description is paradoxically only actualized in a figurative mode through guiding metaphors, then we are (...) compelled to ask after the meaning of such a situation for metaphysics, understood as the "redundance" or "affirmation" of existence in its declaration of itself as truth— precisely, I suggest, the work done by metaphor in its strange interlacing of being and human being in the event of language. (shrink)

In 1948 Van Lohuizen emphasized the importance of cooperation among all parties, and the need to establish continuous links between the scientific, aesthetic, and political dimensions of the planning process, so the necessary knowledge, talent, and insight can be accessed as if combined in one individual, to allow high caliber performance. Similar pleas have been made elsewhere, indicating special kinds of obstacles that affect such performance. In this article these obstacles are identified and interpreted as the result of an ill-match (...) between two approaches. According to the first, coordination and combination will be best when participant actors are modeled into well-defined roles, and their interactions coordinated via those roles. According to the second, differences should be made evident via the use of coordinating languages, leaving maximum freedom to and difference among participants, as voluntary users of those languages. Following the first approach, but not accepting its consequences as valued by the second approach, explains pleas like van Lohuizen’s. They can be fulfilled by explicating the methodology of the second approach. The article tries to provide both: the explanation and (part of the) methodology. (shrink)

That the present day society profits from research in many areas is evident. This has stimulated a keen desire to emulate similarly advantageous contributions in other areas. It appears to imply not only a need to know how to (better) support action in general or any action, but also how to support the act of making "better" itself (better businesses, better houses, better emotions, better objectives, etc.). Developing the latter type of knowledge has proved to pose a major challenge, however. (...) Although the challenge has been taken up in areas such as social policy, economics, therapy, management, architecture, design, and others, leading to a number of responses, a complete characterisation seems still to be lacking. Such a characterisation is attempted in this article. Typical characteristics are the inclusion of non-observational experiences and a simultaneous striving for individual and collective high quality. (shrink)

While there is often good reason to study our world by abstracting properties from its parts to the point where the result can be modelled as mechanisms, there is no need to do so when humans are ….

Open peer commentary on the article “A Cybernetic Approach to Contextual Teaching and Learning” by Philip Baron. Upshot: Philip Baron is challenged to clarify the link between his admirable efforts at teaching and research. To allow for a counterchallenge a method to transfer his experiences is summarised that is equivalent to the scientific method.

Radical Constructivism has been defined as anunconventional approach to the problem ofknowledge and knowing. Its unconventionalityis summarised by its claim that it isimpossible to attribute unique meaning toexperience – as no mind-independent yardstick canbe assumed to exist against which to identifyuniqueness, and hence to produce knowledge andknowing. In other words, it is claimed thatthere is no reality that is knowable to allindividual knowers. This claim appearsindefensible by itself, as it does not explainwhy the successes of traditional science appearas such. However, (...) it is defensible in thecontext of numerous failures to achieve uniqueattributions, or of the history of science.Even so, what is missing are concrete methodsand research designs. This often leaves RadicalConstructivism to be critical only, toconcentrate on justifying the impossibility ofsuccess without contributing itself.Where this is the case it reduces scientiststo individuals considered unable to communicatewith others on public (and unique)attributions-who may do so only by borrowingmethods from previous approaches. It is arguedthat a more valuable contribution is possibleif Radical Constructivism is seen as a responseto the challenge defined by frequent failuresof traditional approaches. The latter may beextended such that the extensions converge toRadical Constructivism. Such extensions arebased on reported observations, rather than onexperiences in general, and are to beattributed meanings – uniquely as well asnon-uniquely – by way of a collective. The lattershould allow its actors to restrict whatmaintains the collective to what is observableto others, as well as use the collective torestrict their own observations. The study ofcollectives thus allows for the study ofrestrictions or values, and hence for includingsubjective or constructivist experiences beyond(reportable) observations. (shrink)

The past 50 years have seen an accumulation of evidence suggesting that associative learning depends on high-level cognitive processes that give rise to propositional knowledge. Yet, many learning theorists maintain a belief in a learning mechanism in which links between mental representations are formed automatically. We characterize and highlight the differences between the propositional and link approaches, and review the relevant empirical evidence. We conclude that learning is the consequence of propositional reasoning processes that cooperate with the unconscious processes involved (...) in memory retrieval and perception. We argue that this new conceptual framework allows many of the important recent advances in associative learning research to be retained, but recast in a model that provides a firmer foundation for both immediate application and future research. (shrink)

Notions of purity, perfection, or immaculateness have powered our imagination over the ages. Various images of perfection have held sway in their hallowed times, providing secure streams for channelling human energy. Unfortunately, with the unfolding of the human drama on the world stage, all the images of perfection have suffered damage, epoch on epoch. Different responses have emerged to attempt a restoration. Revival of some of the old images is one such response. Production of new images to serve as worthwhile (...) anchors of value and meaning is another common response. For reasons possibly known only to philosophers and historians, the enterprise called modern science has got thickly embroiled in this civilisational process--first, as the culprit behind the decline of some of the established images, then as the producer of new images, and now, perhaps, as a constant reminder of the perpetual lack of purity and immaculateness in all things human. (shrink)

(2006). Introduction. World Futures: Vol. 62, No. 3, pp. 153-156.

Background Reasonable disagreement about the role awarded to gamete donors in decision-making on the use of embryos created by gamete donation for research purposes emphasises the importance of considering the implementation of participatory, adaptive, and trustworthy policies and guidelines for consent procedures. However, the perspectives of gamete donors and recipients about decision-making regarding research with EGDs are still under-researched, which precludes the development of policies and guidelines informed by evidence. This study seeks to explore the views of donors and recipients (...) about who should take part in consent processes for the use of EGDs in research. Methods From July 2017 to June 2018, 72 gamete donors and 175 recipients completed a self-report structured questionnaire at the Portuguese Public Bank of Gametes. Agreement with dual consent was defined as the belief that the use of EGDs in research should be consented by both donors and recipients. Results The majority of participants were willing to donate embryos for research. Almost half of the donors and half of the recipients considered that a dual consent procedure is desirable. This view was more frequent among employed recipients than among non-employed. Donors were less likely to believe that only recipients should be involved in giving consent for the use of EGDs in research and were more frequently favourable to the idea of exclusive donors’ consent. Conclusions Divergent views on dual consent among donors and recipients indicate the need to develop evidence-based and ethically sustainable policies and guidelines to protect well-being, autonomy and reproductive rights of both stakeholder groups. More empirical research and further theoretical normative analyses are needed to inform people-centred policy and guidelines for shared decision-making concerning the use of EGDs for research. (shrink)

In this response, we provide further clarification of the propositional approach to human associative learning. We explain why the empirical evidence favors the propositional approach over a dual-system approach and how the propositional approach is compatible with evolution and neuroscience. Finally, we point out aspects of the propositional approach that need further development and challenge proponents of dual-system models to specify the systems more clearly so that these models can be tested.

Positive frequency dependent selection is a natural selection regime where the fitness of a phenotype increases with its frequency in the population. Examples can be typically found in the spread of disease tolerance strategies in a population. A characterizing feature of PFDS is that the focal allele may experience favorable selection only when it becomes more frequent in the population, while being selected against when it is rare. In this paper, by applying a solution concept from evolutionary game theory, we (...) hypothesize that the process of emergence of such alleles triggers selection for silence, where the emergence of alleles that can stay unexpressed for a period of time will be favored by selection forces. We illustrate our hypothesis using a mathematical model of a population of single locus diploid organisms with two alleles where a single mutant of an allele that experiences positive frequency dependent selection appears in a population where the other allele is a dominant. The model results show that the longer the silence interval of the new mutant before its expression, the better its chances of getting fixed in the population. However, this effect will be observable only to a certain limit after which further increase in the interval will not have an effect on the expected fixation rate. Two divergences from the simple scenario are also investigated: the nonsynchronous expression of the focal allele and its emergence in a spatial grid limited by a migration bottleneck. In all cases, it is shown that there is an evolutionary pressure inherent in the dynamics of positive frequency dependent selection on the genes to have a delayed expression. It is hypothesized that the regulation systems of such traits will be under selection for either internal silencing mechanisms or to be triggered by an external environmental condition. (shrink)

O envelhecimento populacional é uma preocupação mundial e exige medidas de prevenção de saúde a serem adotadas com a maior brevidade possível. Esse processo é, muitas vezes, acompanhado pelo declínio das habilidades cognitivas, como a memória e as funções executivas. O objetivo do presente estudo é ..

We can understand viewed scenes and extract task-relevant information within a few hundred milliseconds. This process is generally supported by three cortical regions that show selectivity for scene images: parahippocampal place area (PPA), medial place area (MPA) and occipital place area (OPA). Prior studies have focused on the visual information each region is responsive to, usually within the context of recognition or navigation. Here, we move beyond these tasks to investigate gaze allocation during scene viewing. Eye movements rely on a (...) scene’s visual representation to direct saccades, and thus foveal vision. In particular, we focus on the contribution of OPA, which is i) located in occipito-parietal cortex, likely feeding information into parts of the dorsal pathway critical for eye movements, and ii) contains strong retinotopic representations of the contralateral visual field. Participants viewed scene images for 1034 ms while their eye movements were recorded. On half of the trials, a 500 ms train of five transcranial magnetic stimulation (TMS) pulses was applied to the participant’s cortex, starting at scene onset. TMS was applied to the right hemisphere over either OPA or the occipital face area (OFA), which also exhibits a contralateral visual field bias but shows selectivity for face stimuli. Participants generally made an overall left-to-right, top-to-bottom pattern of eye movements across all conditions. When TMS was applied to OPA, there was an increased saccade latency for eye movements toward the contralateral relative to the ipsilateral visual field after the final TMS pulse (400ms). Additionally, TMS to the OPA biased fixation positions away from the contralateral side of the scene compared to the control condition, while the OFA group showed no such effect. There was no effect on horizontal saccade amplitudes. These combined results suggest that OPA might serve to represent local scene information that can then be utilized by visuomotor control networks to guide gaze allocation in natural scenes. (shrink)